This podcast episode explores Alzheimer’s disease, its diagnosis and risk factors, with a focus on the impact of genetic variants and lifestyle modifications. The hosts discuss innovative biomarker advancements and the role of genes like PSEN1, PSEN2, APP, and APOE4, emphasizing the importance of comprehensive risk assessment and genetic testing. They highlight the higher risk among women for Alzheimer's disease compared to men, and the potential protective effects of healthy lifestyle factors in mitigating cognitive decline, particularly in individuals with the APOE4 gene variant. The episode promotes awareness, encourages research, and stresses the significance of early detection and preventative measures.