This episode explores the potential of genetic engineering and synthetic biology to solve pressing global challenges, focusing on the work of Ben Lamm and his company, Colossal. Lamm discusses the parallel path approach to de-extinction, citing the woolly mammoth project and the regulation of the p53 gene in Asian elephants as examples of how seemingly disparate research areas can converge. More significantly, the conversation shifts to the broader applications of these technologies, including conservation efforts, human healthcare advancements, and inspiring future generations of scientists. As the discussion pivots to human longevity, Lamm predicts that within 15-20 years, science will add a year of life for every year lived, driven by breakthroughs in blood cleansing and targeted therapeutics. In contrast to focusing solely on human applications, Lamm highlights the potential of synthetic biology to address environmental issues, such as plastic degradation using engineered microbes and engineering plants to build sustainable cities. The episode concludes with Lamm's vision for a future where AI, computation, and synthetic biology converge to solve complex challenges and inspire innovative solutions for ecological balance and human well-being.