This episode explores the therapeutic potential of psychedelics, particularly MDMA, and the ongoing challenges of legalization and acceptance. Rick Doblin recounts his journey advocating for psychedelic research and therapy, including training therapists in Ukraine and planning future work in Beirut. Against the backdrop of personal anecdotes, such as smoking pot with Larry Hagman, Doblin highlights the frustration with the slow pace of legalization, tracing back to the criminalization of MDMA in 1985 and the DEA's resistance. More significantly, the conversation pivots to the therapeutic benefits, including Ibogaine's impact on veterans with PTSD and MDMA's potential in couple's therapy, while also addressing the importance of therapeutic context and integration. For instance, studies combining MDMA with cognitive behavioral conjoint therapy have shown remarkable results in reducing PTSD and strengthening relationships. The discussion also touches on the complexities of double-blind studies and the FDA's cautious approach, while emerging industry patterns reflected in the growing psychedelic renaissance offer hope for future progress.