This episode explores the potential impacts of AI on society, focusing on the next 5, 25, and 100 years. Andy Weir predicts disruptions in the graphic arts and entertainment industries, with AI potentially democratizing content creation and tailoring entertainment experiences to individual preferences. Against the backdrop of personalized entertainment, concerns arise about the loss of shared narratives and the potential for societal fragmentation, though Weir argues that this decentralization could liberate individuals from top-down narrative control. As the discussion pivots to material science, Weir envisions AI accelerating breakthroughs in areas like vaccine development and personalized medicine, potentially leading to novel treatments for diseases like cancer. More significantly, the conversation delves into the ethical implications of AI-driven genetic engineering, including the possibility of "designer babies" and cosmetic ethnicity, raising complex questions about human autonomy and societal values. For instance, Weir speculates about the potential for individuals to alter their ethnicity or metabolic processes through genetic modifications. The emerging industry patterns reflected in this discussion highlight the transformative power of AI, balanced with the need for careful consideration of its ethical and societal consequences.