This podcast episode explores the potential of psychedelics, such as psilocybin, in treating mental health disorders. Dr. Robin Carhart Harris, a renowned neurologist and psychiatrist, discusses his research on how psychedelics affect neural circuitry in the brain. Clinical trials conducted by his laboratory have shown promising results in alleviating major depression with psilocybin therapy. The podcast delves into the evolution of legislation surrounding psychedelics, as well as the therapeutic outcomes and potential long-term changes that can occur with their use. The episode also delves into the nuances of microdosing and dosage conversion, the role of music in psychedelic therapy, and the importance of "letting go" during the psychedelic experience. Additionally, it explores the concept of ego and its modulation during psychedelic therapy sessions. The podcast raises questions about the future of psychedelic therapy, discusses ongoing clinical trials, and emphasizes the need for responsible integration and further research to fully understand the therapeutic potential and mechanisms of action of psychedelics.