This episode explores strategies for improving sleep quality and managing stress, particularly in the context of travel and hectic lifestyles. It addresses the impact of biological and psychological anxiety on sleep, highlighting the "tired but wired" phenomenon. Matt Walker suggests supplements like phosphatidylserine and ashwagandha to help manage stress and cortisol levels, while Arianna Huffington emphasizes the importance of controlling what one can, such as limiting news consumption and notifications. The discussion pivots to jet lag, with Walker recommending adjusting to the new time zone immediately upon arrival, strategic napping, and exposure to daylight. Walker also cautions against the overuse of melatonin, especially in children, and the potential downsides of relying on modafinil regularly, while stressing that there are typically no free lunches in biology. Arianna Huffington adds that joy and overall life experience are important barometers, not just numbers, when evaluating well-being and the impact of sleep habits. The episode concludes with a discussion on the positive impact of sex on sleep quality.