This episode explores the science of aging and longevity, featuring Dr. Eric Topol, who shares evidence-based approaches to extend healthspan and prevent age-related diseases. Dr. Topol challenges the anti-aging industry's claims, emphasizing that lifestyle adjustments are more effective than supplements or unproven treatments. He advocates for "Lifestyle Plus," which includes diet, exercise, sleep, social connections, and environmental awareness, to combat major diseases like cancer, heart disease, and dementia. Against the backdrop of rising rates of chronic diseases, Dr. Topol highlights the importance of early prevention through personalized risk assessments and lifestyle changes, noting that these diseases typically take over 20 years to develop, offering a window for intervention. More significantly, the discussion pivots to the role of diet, particularly ultra-processed foods, in accelerating aging and promoting inflammation, while also addressing the benefits of coffee and the limited value of supplements. Emerging from this conversation is a call to action for individuals to prioritize lifestyle choices and mental well-being, supported by advancements in medical science and AI, to achieve healthier and longer lives.