This podcast episode explores the importance of muscle health, particularly in aging populations and individuals with certain conditions. It discusses the decline of muscle mass as we age and the detrimental effects of periods of illness or inactivity on muscle mass. The use of DEXA for measuring muscle health is examined, along with the significance of considering muscle strength and function. The impact of the disuse model on muscle mass and the potential greater muscle mass loss in overweight or obese individuals with diabetes or insulin resistance are also discussed. The importance of diet, protein distribution, and fasting for muscle health is explored. Additionally, the quality of dietary protein, the variation in muscle loss, the effects of bed rest on hyperglycemia and insulin sensitivity, and the impact of sleep deprivation on physical function and muscle health are highlighted. The podcast also addresses the challenges of feeding a growing population, the need to shift the focus to individual essential amino acids, and the importance of considering sex-based differences in muscle research.