This episode of the Core IM 5 Pearls podcast features Dr. Shreya Choudhury and Dr. Ian Kelly discussing lipoprotein A (Lp a). They consult with experts like Dr. Coco Frasch, Dr. Steve Nissen, and Dr. Gregg Katz to explain what Lp a is, who should be tested, how to interpret levels, and how to manage elevated levels. The podcast covers Lp a's role in increasing ASCVD risk, its genetic determinants, and the importance of aggressive management of other risk factors. They also discuss potential future treatments and the nuances of aspirin and PCSK9 inhibitors in managing patients with elevated Lp a. The episode emphasizes tailoring management to individual patients and highlights the significance of understanding Lp a in cardiovascular risk assessment.