This episode explores the Sackler family's transformation from celebrated philanthropists to figures widely condemned for their role in the opioid crisis. Against the backdrop of their initial success with Valium, the Sacklers' aggressive marketing of OxyContin is analyzed, highlighting the use of manipulative tactics such as reframing the drug's addictive nature, employing specific data points to build trust, and leveraging the mere exposure effect and authority bias. More significantly, the podcast details how Purdue Pharma, owned by the Sacklers, used endorsements from doctors, pain groups, and celebrities to avoid audience reactance and shift public perception. For instance, the repeated use of the misleading 1% addiction statistic is examined. The consequences of this campaign, including widespread addiction and numerous deaths, are presented, leading to lawsuits and a $7.4 billion settlement. Ultimately, the episode concludes by highlighting the devastating impact of the opioid crisis and the Sacklers' role in fueling it, while also mentioning resources for those affected.