The podcast discusses the correlation between exercise and dementia risk. Rhonda Patrick highlights a longitudinal study showing a strong inverse relationship between cardiorespiratory fitness (measured by VO2 max) and Alzheimer's risk in women. She contrasts this with studies relying on self-reported activity levels, which showed no such association. Peter Attia emphasizes the objectivity of VO2 max as a measure, suggesting that the intensity or type of exercise might be less crucial than the resulting fitness level. The conversation also briefly touches upon potential gender differences in exercise response and the role of myokines in the brain and overall health.
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