This episode explores the ongoing global tuberculosis (TB) crisis and its intersection with social injustice and human connection, featuring an interview with author John Green. Against the backdrop of Green's new book, *Everything is Tuberculosis*, the discussion details the staggering number of annual TB deaths—a preventable tragedy stemming from inadequate funding and healthcare access. More significantly, the conversation highlights the profound stigma surrounding TB, often making the social burden of the disease more debilitating than the illness itself; for instance, Green recounts his encounter with a young TB patient in West Africa whose experience exemplifies this harsh reality. As the discussion pivoted to happiness, Green and Dr. Laurie Santos (the podcast host) explored the importance of hope and earnestness in confronting suffering, contrasting toxic positivity with a more nuanced understanding of finding meaning in the face of adversity. The conversation further delved into the role of community and shared experiences in combating despair, emphasizing the power of collective action and the importance of acknowledging and addressing suffering openly. Finally, the episode concludes with reflections on the fragility of life and the importance of finding small joys amidst hardship, underscoring the human capacity for resilience and generosity even in the face of immense challenges. This episode demonstrates the power of narrative in raising awareness about global health issues and inspiring action.