This episode explores the application of AI in drug discovery, specifically within Reid Hoffman's newly launched company, Manas AI. Against the backdrop of Hoffman's extensive experience in scaling businesses, the discussion delves into his decision to co-found Manas, highlighting the unique combination of his AI expertise and Siddhartha Mukherjee's oncology research. More significantly, the conversation examines Manas's strategic approach to leveraging existing AI technologies and selectively building proprietary solutions, emphasizing a focus on achieving substantial improvements (10x or greater) rather than reinventing the wheel. For instance, the partnership with Microsoft is cited as a way to access cutting-edge technology without extensive internal development. As the discussion pivots to the competitive landscape, Hoffman emphasizes the importance of focused, iterative funding rounds, contrasting this with the often less successful strategy of raising excessive capital upfront. Finally, the episode touches upon the challenges of navigating regulations in the healthcare industry and offers insights into how businesses can effectively integrate AI into their operations, emphasizing the importance of identifying areas where AI can provide a true competitive advantage.