This episode explores the science of maintaining brain health as we age, interviewing clinical neuropsychologist Dr. Vonetta Dotson. Against the backdrop of a 42% risk of dementia after age 55, the discussion highlights lifestyle factors crucial for reducing this risk. More significantly, Dr. Dotson emphasizes physical activity as the most impactful intervention, capable of stimulating neuron growth and improving brain function. As the discussion pivoted to mental activity, she advocates for engaging in novel and challenging cognitive tasks, while cautioning against the limited effectiveness of commercial brain training games. Furthermore, the importance of fulfilling social connections and sufficient, uninterrupted sleep was underscored. In contrast to the notion of a single optimal diet, Dr. Dotson promotes a Mediterranean-style approach emphasizing whole grains and fresh produce. Finally, the interview concludes by addressing health disparities in cognitive aging, highlighting the impact of chronic stress and advocating for multi-level interventions, including primary care integration and community-based programs, to promote brain health equity.