This episode explores the multifaceted benefits of creatine supplementation, moving beyond its common association with strength and power gains. Against the backdrop of Dr. Darren Candow's extensive research (over 140 peer-reviewed papers), the discussion reveals creatine's potential roles in cognitive function (especially under stress or sleep deprivation), muscle and bone health (particularly in aging populations), endurance performance, and even mental health conditions like depression. More significantly, the interview delves into the specifics of creatine supplementation, addressing optimal dosage (ranging from 3-5 grams daily, with higher doses potentially beneficial for bone and brain health), loading phases, and the efficacy of different creatine formulations (monohydrate being the gold standard). For instance, the conversation highlights the anti-inflammatory effects of creatine, particularly relevant for endurance athletes and potentially aiding recovery from intense workouts. The episode concludes by emphasizing the need for further research, particularly in areas like the effects of creatine on bone mineral density and its role in preventing or treating neurodegenerative diseases, while acknowledging the current evidence supporting its overall safety and efficacy.