This episode explores interoception as a potential mechanism through which yoga and mindfulness practices alleviate persistent pain. Against the backdrop of a recent paper (Voss et al., 2023) which hypothesized this connection, the discussion delves into the complexities of interoception, breaking it down into specific components like accuracy, sensibility, and awareness. More significantly, the conversation highlights that yoga's benefits extend beyond pain management, impacting mental and emotional well-being. For instance, the neural correlates of interoception, involving brain regions responsible for stimulus prioritization, are discussed, emphasizing the cognitive aspect of pain perception and stress response. The hosts and guest agree that while research on yoga's mechanisms is still developing, the consistent positive impact on well-being is undeniable. This means for yoga practitioners and instructors that diverse approaches to cultivating interoceptive awareness are valuable, as individuals connect with the practice through physical, mindfulness, or spiritual aspects. Ultimately, the episode underscores the importance of trusting the process of yoga and its inherent ability to promote well-being, regardless of the specific techniques employed.