This episode of "How I Built This" features an interview with Dennis and Carrie Gross, founders of Dr. Dennis Gross Skincare, a $450 million brand. The podcast traces their journey from Dennis's dermatology practice, where he developed a novel, less irritating skin peel, to building a successful skincare company. The Grosses discuss their initial bootstrapping, the challenges of a lawsuit forcing a name change to Dr. Dennis Gross Skincare, and their eventual acquisition by Shiseido. A key takeaway is their emphasis on product efficacy and a strong brand identity built on Dennis's medical expertise and Carrie's business acumen. The couple's story highlights the importance of innovation, perseverance, and adapting to market changes, even during crises like the 2008 financial crisis and the COVID-19 pandemic.