This podcast episode interviews Sean Fury, a writer and filmmaker, about his experience with treatment-resistant depression and his use of Spravato, a ketamine-derived nasal spray, as a treatment. The interview details Sean's struggles, his decision to try Spravato, and the positive impact it has had on his life, including improved mood and increased confidence. The podcast also features an interview with Dr. Hosseini Manji, a neuroscientist involved in Spravato's development, who explains the science behind the drug and the challenges of bringing it to market. Spravato's success story highlights the pharmaceutical industry's growing interest in psychedelic treatments for mental health conditions. The episode concludes with Sean discussing his new film, "The Hard Way," which reflects his journey with depression.