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A nanogel coupled with a cell-penetrating compound more effectively delivers antibiotics to kill bacteria that hide within bladder lining cells and perpetuate urinary tract infections. Pharmacologists and microbiologists from the University of Colorado’s Anschutz Campus report the successful development and deployment of just such a drug.

The researchers combined polymeric nanogels with a peptide compound that eases their cellular entry and the antibiotic gentamicin in order to effectively kill pseudomonas bacteria that hide within bladder lining cells. When injected into the bladder, this nanogel-peptide-antibiotic complex is able to convey 36% more of the antibiotic into the cell interior than conventional administration techniques. When tested in animal models, it successfully eliminates more than 90% of bladder bacteria.

This technique shows great promise for more effective management of not only persistent and recurrrent bladder infections but also tenacious infections elsewhere in the urinary tract and other organs.

https://www.sciencedirect.com/science/article/abs/pii/S1549963425000127?via=ihub

https://www.sciencedaily.com/releases/2025/03/250312124140.htm#google_vignette

#cystitis #bladder #infection #itaconate #nanogel #gentamycin

Nano-eradication of Recurrent Bladder Infections

Dr. Howard Smith Reports