This episode explores the application and integration of Motivational Interviewing (MI) in various therapeutic settings, particularly with adolescents. Against the backdrop of the speaker's experience using traditional methods that proved ineffective in achieving behavioral change with young people, the discussion details the discovery and implementation of MI. More significantly, the interview highlights the unexpected positive impact of MI on depression scores, even when not directly targeted, and emphasizes the importance of emphasizing autonomy in therapeutic interactions. For instance, the speaker shares a case study of a young person who, despite possessing the necessary skills, lacked the motivation to utilize them, underscoring the importance of understanding intrinsic motivation. The conversation further delves into the integration of MI with Cognitive Behavioral Therapy (CBT) and Multisystemic Therapy (MST), showcasing research findings and practical strategies for effective implementation. Finally, the episode concludes with insights into ongoing research focusing on optimizing MI training and implementation across various settings, emphasizing the need for flexible and adaptable approaches to suit diverse organizational contexts and resource limitations.