This episode of "Stuff You Should Know" discusses influenza, differentiating it from the common cold and detailing its transmission and symptoms. The hosts explain the influenza virus's mechanism of infection, its rapid replication within respiratory cells, and the resulting inflammation. They also cover complications like pneumonia and dehydration, emphasizing the importance of handwashing and staying home when sick. Finally, they discuss flu vaccines, their effectiveness, and the ongoing research for a universal flu vaccine.