This podcast interviews Dr. Herman Pontzer, an evolutionary anthropologist, about his research on human metabolism and energy expenditure. The discussion covers his surprising findings on hunter-gatherer energy expenditure, debunking common misconceptions about exercise and weight loss, and explaining the body's regulatory mechanisms for maintaining energy balance. Pontzer emphasizes that weight gain is primarily determined by caloric intake, not expenditure, and that exercise's primary benefits extend beyond caloric burn to include improved health and physiological regulation. He highlights that a woman's pregnancy is a metabolically demanding process, potentially impacting fertility, and that individual variation in metabolism is significant, advocating for a personalized approach to health and fitness. The interview concludes with a discussion on the limitations of population-level research in understanding human physiology and the importance of considering individual differences.