This podcast episode discusses Warren Buffett's 2024 annual letter and Berkshire Hathaway's annual report, focusing on Buffett's cautious outlook and Berkshire's massive cash reserves ($334 billion). The hosts then analyze Apple's $500 billion US investment plan over four years, speculating that this signifies a major push into AI-powered services, potentially centered around an improved "Apple Intelligence" system. Finally, the discussion shifts to MindMed's Phase 3 trial using LSD to treat anxiety and depression, highlighting the potential for a single-dose, long-lasting treatment and comparing it to existing therapies. A key takeaway is the significant potential of psychedelics in mental health treatment, despite regulatory hurdles. The episode concludes with a discussion of the potential use of LSD in early-stage dementia.