This Joe Rogan Experience episode features an interview with Woody Harrelson, primarily focusing on their shared concerns about pharmaceutical profiteering and government overreach, particularly regarding the COVID-19 pandemic and vaccine mandates. The conversation flows from Harrelson's recent controversial Saturday Night Live monologue to broader discussions about political manipulation, media bias, and the potential benefits of psychedelic drugs. Specific examples include their critique of Pfizer's profits and the alleged suppression of early COVID treatments. Listeners gain insights into the perspectives of two high-profile figures on these controversial topics and are encouraged to critically evaluate information sources.