This TED Talk Daily podcast features neuroscience researcher Riccardo Loconte discussing the use of AI in lie detection. Loconte begins by highlighting humans' poor lie-detection abilities (around 50% accuracy, similar to a coin flip), then details his research using Google's Fluency5 language model to analyze datasets of truthful and deceptive statements. The AI achieved 70-80% accuracy in some tests but struggled to generalize across different contexts. While AI shows promise in lie detection, Loconte cautions against blind trust in AI outputs, emphasizing the need for interpretability and critical thinking to avoid eroding human trust. The podcast concludes with a call for responsible AI development and ethical considerations.