This episode of "Stuff You Should Know" explores the history and impact of refrigeration. The hosts discuss the evolution of cooling techniques, from ancient methods like using saltpeter and evaporative cooling to the invention of mechanical refrigeration and the development of the cold chain. They highlight the significant role refrigeration played in transforming food availability and diets, particularly in America, citing the eradication of "spring sickness" and the rise of the meatpacking industry. The impact on food distribution is illustrated by the drastic price drop of pears, from 40 cents to two for a nickel. Finally, the hosts touch upon the development of home refrigeration and frozen foods, emphasizing the societal changes brought about by these advancements.