This episode explores the mind-body problem, investigating the relationship between consciousness and the physical brain. The discussion begins with an overview of three proposed solutions: dualism (the existence of an immaterial soul), functionalism (the mind as a computer program), and physicalism (consciousness as a biological brain function). Against this backdrop, the host interviews philosophers representing different viewpoints, including a physicalist who emphasizes the importance of biological substrates and a dualist who argues for a non-physical element. More significantly, the conversation delves into the challenges of replicating consciousness in non-biological systems, raising questions about the essence of phenomenal experience and whether it's solely dependent on specific physical structures. For instance, the debate touches upon the possibility of creating "zombies"—functionally identical beings lacking subjective experience. In contrast, a parapsychologist introduces the concept of internal ESP as a potential mechanism for brain-mind interaction, highlighting the limitations of traditional approaches. Ultimately, the episode concludes by suggesting that a radically new understanding, either involving undiscovered physical phenomena or acknowledging non-physical elements, is needed to fully grasp consciousness. What this means for our understanding of the nature of reality and the potential for artificial consciousness remains open to further exploration.