This Brains On! episode explores the science of salt, its culinary uses, and its importance to human health. The show begins with a humorous skit, then delves into the chemical composition of salt (sodium chloride), explaining its role in taste perception and bodily functions. A food journalist guest discusses the importance of salt in cooking and offers tips on adjusting salt levels in recipes based on personal preference. The episode concludes with a listener's question and a mystery sound segment. Listeners learn that salt crystals come from the ground or seawater and that our brains are wired to find salt delicious because our bodies need it.