This week, Matt Walker dives into the world of the widely used sleeping pill, Ambien (Zolpidem). He explains how Ambien, a non-benzodiazepine sedative-hypnotic, works by targeting the brain's GABA receptors, specifically the alpha-1 subunit, to induce sleep. However, this comes with consequences. Matt highlights research by Dr. Marcos Frank showing that Ambien significantly impairs memory consolidation, essentially unwiring the brain's learning processes during sleep by approximately 50%.

Furthermore, the episode explores Ambien's impact on the glymphatic system, the brain's crucial waste removal process active during deep sleep. New research demonstrates that Ambien reduces the glymphatic system's cleaning capacity by about 32%, potentially hindering the removal of harmful proteins linked to Alzheimer's disease. While Ambien may offer a temporary solution for insomnia, these findings underscore the importance of natural, restorative sleep for long-term brain health. The discussion advocates for such alternative treatments as Cognitive Behavioral Therapy for Insomnia (CBTI) that address sleep issues without compromising essential neural functions.

Please note that Matt is not a medical doctor, and none of the content in this podcast should be considered medical advice in any way, shape, or form, nor prescriptive in any way.

One of our sponsors this week is the biochemical electrolyte drink company LMNT, and they are very kindly offering eight free sample packs when you purchase any one of their orders at drinklmnt.com/mattwalker. LMNT is an electrolyte sports drink that I can get behind - it's created from the basis of science, and it has no sugar, no coloring, and no artificial ingredients – all qualities that are so important to maintaining your blood biochemical balance. If you want to give LMNT a try, just head on over to drinklmnt.com/mattwalker and get your eight free samples with your first purchase.

Matt will be the first to tell you that launching his sleep-related merchandise sales was incredibly smooth, thanks to our new sponsor Shopify and their integrated sales and inventory system. And now, just for you, Shopify is generously offering an exclusive trial at shopify.com/mattwalker. Whether it's online or in-person sales, Shopify simplifies it all. So, be sure to stop in at shopify.com/mattwalker to start your exclusive journey now!

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As always, if you have thoughts or feedback you’d like to share, please reach out to Matt:

Instagram @drmattwalker

X @sleepdiplomat

YouTube: https://www.youtube.com/@sleepdiplomatmattwalker9299

#91 Sleep, Ambien, Memory, and Alzheimer's

The Matt Walker Podcast