This Fresh Air interview podcast explores the increasing trend of social isolation in the 21st century, a phenomenon writer Derek Thompson calls the "anti-social century." Thompson argues that this trend, which began decades ago with the rise of the car and television, has been exacerbated by smartphones, leading to increased solitude without necessarily increased loneliness. He distinguishes between solitude (chosen alone time) and loneliness (a gap between desired and felt social connection), highlighting how technology might deplete dopamine levels, making social interaction seem less appealing. The discussion also touches on the impact of this isolation on political polarization and the role of social media, suggesting that increased alone time may contribute to political tribalism and a lack of understanding between opposing groups. Ultimately, Thompson advocates for increased face-to-face interaction as a solution, emphasizing the importance of small, everyday social interactions.