In this episode, Steven Bartlett interviews a guest about the neuroscience behind building self-esteem and confidence. The discussion covers the importance of identifying and counteracting negative thought patterns with positive affirmations, the power of language and neuroplasticity in shaping beliefs, and the concept of manifestation grounded in cognitive science. The guest emphasizes that manifestation isn't about magically attracting things but about making changes based on one's thought processes. They also touch on the significance of personal responsibility and the impact of language on one's mindset, advocating for conscious word choices to empower oneself. The episode concludes with practical advice on visualizing desired outcomes and practicing gratitude to shift the brain from a fear state to a trust state, which is presented as the initial step toward personal growth.