This episode explores the intersection of science, public health, and political appointments, focusing on several concerning nominations within the US health sector. Against the backdrop of ongoing concerns about the handling of the COVID-19 pandemic, the panelists discuss the nomination of Jay Bhattacharya as NIH director, citing his controversial views on the pandemic's origins and handling as cause for alarm. More significantly, the nomination of Robert F. Kennedy Jr. for the Director of Health and Human Services is heavily criticized due to his anti-vaccine stance and proposed cuts to infectious disease research. For instance, Kennedy Jr.'s plan to cut infectious disease research for eight years is viewed as incredibly short-sighted given the current H5N1 avian flu outbreak. The discussion then pivots to a more positive note, analyzing a JAMA Network article demonstrating the effectiveness of the HPV vaccine in reducing cervical cancer mortality among young women. In contrast to the political controversies, this showcases the positive impact of scientific research on public health. Finally, the panelists delve into a recent study on the transmissibility of an H5N1 avian flu strain acquired from a cow, highlighting the potential pandemic risk and the need for continued infectious disease research. What this means for the future of scientific research and public health in the US remains uncertain, given the current political climate.