TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Links for this episode

MicrobeTV Discord Server
MicrobeTV store at Cafepress
Research assistant position in Rosenfeld Lab CBER/FDA (pdf)
VITT-like disorder after adenovirus infection (NEJM)
The clot thickens (TWiV 842)
Lessons from VITT (Nat Rev Immunol)
Pan-sarbecovirus neutralizing mAb (Sci Adv)
Letters read on TWiV 1037
Timestamps by Jolene. Thanks!

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Dickson – Rho Ophiuchi nebula showing massive star formation. James Webb Space Telescope
Brianne – Question Mark in Space?
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Vincent – Matters Microbial

Listener Picks

Tom – The (second) deadliest virus
Charles – We Will All Go Together When We Go and So Long Mom (A Song for World War III)
Intro music is by Ronald Jenkees

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TWiV 1037: Antibodies, the good (CoV), the bad (Ad), the beautiful

This Week in Virology