In his weekly clinical update, Dr. Griffin dives into H5N1/influenza and RSV circulation in the US, whether or not H5N1 is “adapting” for human-human transmission, why drinking raw milk may NOT be the best idea despite RFK Jr endorsement, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how if I encounter no one I can infect no one, the efficacy of COVID-19 boosters, how vaccines are the ‘seat belt’ of public health, the results of two PLACEBO control studies assessing antiviral therapy for COVID-19, where to find PEMGARDA, susceptibility of neurological complications in young to middle-aged adults and how discussing the origins of the pandemic and rise of scientific harassment will allow you to avoid a political conversation around your Thanksgiving day table, the interplay between transmission and immunity for virus spread and who to call if you do get sick this holiday. Happy Thanksgiving!

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Links for this episode

Influenza weekly surveillance report: cliff notes (CDC FluView)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
In case you missed, US respiratory virus activity (CDC Respiratory Illnesses)
Adaptation of H5N1 to humans…..sequence analysis (Nature)
Favoring human transmission for H5N1 ?(Youtube: medcram)
From 2022: unprecedented bird flu outbreaks sweeping the world…..and we are still talking about it? (Nature)
What children get flu: First child in US infected with H5N1 (CDC Newsroom)
Bird flu detected in raw milk……but RFK at HHS says it is safe? (NBC News)
COVID-19 deaths (CDC)
COVID-19 national and regional trends (CDC)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
If I see no one in my house, household Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Transmission is reduced! (CID)
Updated boosters conferred protection against SARS-CoV-2 infection and emergency visits/hospitalizations during a JN.1 variant wave(CID)
Provisional COVID-19 mortality (CDC National Center for Health Statistics)
Influenza, RSV and COVID-19 vaccine in nursing home residents (CDC MMWR)
Vaccines are the seat belts of public health (TRID)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
Fusion center near you….if in NY (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Effectiveness of molnupiravir against 30-day mortality among 74 541 SARS-CoV-2 positive patients (OFID)
Sustained Recovery Among Outpatients With COVID-19 Receiving Montelukast vs Placebo(JAMA Network Open)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Steroids, dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Remdesivir for treatment of COVID-19 requiring oxygen support (CID)
Daniel Griffin’s evidence based medical practices for long COVID (OFID)
Neurologic manifestations of long COVID disproportionately affect young and middle-aged Adults (Annals on Neurology)
To review, three score and two months ago, the WHO brought for on this planet, the declaration of SARS-CoV-2/COVID-19….
How nature began a pandemic (microbeTV)
Bullying within the origin scientific discourse……by those at Rutgers (Science)
Scientific harassment on the rise (Science)
Doxing :The de-identified of the de-identified (Wikipedia)
Harassment survey (Science)
The harm of factless hypotheses (mSphere)
In summary, the era of harm: factless theories (microbeTV)
Stay inside: risk of SARS-CoV-2 transmission in community indoor settings (JID)
Lower levels of household transmission of SARS-CoV-2 VOC Omicron compared to Wild-type: an interplay between transmissibility and immune status (JID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
Letters read on TWiV 1170
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1170: Clinical update with Dr. Daniel Griffin

This Week in Virology