This lecture focuses on hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP), particularly their management outside of intensive care units (ICUs). The speaker addresses the difficulties of researching ICU patients due to their high mortality rates and underscores the critical need for early detection and timely escalation of care for HAP. In non-ICU settings, the use of high-flow nasal oxygen and non-invasive ventilation is explored, with an emphasis on the importance of regular reassessment and prompt ICU referral when necessary. For VAP, a comprehensive approach that includes care bundles and careful antibiotic management is recommended, along with insights from recent studies on antibiotic duration and inhaled aminoglycosides. The key takeaway is the necessity for early intervention, appropriate escalation of care, and collaborative teamwork in effectively managing these conditions.