In this podcast episode, Dean Carignan discusses Microsoft's journey toward responsible AI, highlighting six core principles that guide their AI initiatives: fairness, reliability and safety, inclusiveness, privacy and security, accountability, and transparency. Carignan addresses the socio-technical risks posed by AI and the rapid rate of technological advancements, advocating for flexible risk management strategies. He outlines Microsoft’s comprehensive approach, which consists of research, internal policies, and engineering—comparable to the three branches of government. The conversation also delves into exciting new AI opportunities, such as multimodal and multilingual systems, along with agentic systems. Throughout, he emphasizes the importance of transparency and red teaming to effectively navigate the evolving risks associated with these innovations.