In this episode of the NPR Up First podcast, several important news stories are highlighted. The discussion begins with President-elect Trump's nomination of Robert F. Kennedy Jr. to head the Department of Health and Human Services, noting Kennedy's controversial stance on vaccines and various health topics. The podcast then shifts to the bond market's unfavorable response to Trump's economic proposals, raising concerns about inflation and the growing national debt. Lastly, it covers President Biden's meeting with Chinese President Xi Jinping in Peru, emphasizing the importance of maintaining stable relations during the U.S. power transition.