This podcast explores the effects of psilocybin on the human brain, focusing on how it impacts brain networks and subjective experiences. Joshua Siegel, with expertise in systems neuroscience and psychiatry, discusses his research using precision functional mapping to study psilocybin's effects. The conversation highlights how psilocybin desynchronizes brain activity, particularly within the default mode network, correlating with reported feelings of ego dissolution and altered perceptions of space and time. The discussion also covers how engaging in tasks during a psilocybin trip can diminish the drug's effects, illustrating a "grounding" phenomenon. Additionally, the podcast touches on the challenges of placebo-controlled studies with psychedelics, considering the influence of expectation and the potential for both positive and negative biases.
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