In this podcast episode, we explore three groundbreaking scientific discoveries. First, we delve into the mysterious Siberian craters formed by thawing permafrost that releases methane. Next, we discuss how breaking Bredt's Rule in chemistry is paving the way for new advancements in drug development and materials science. Finally, a study reveals that evolution may be more predictable than we once believed, thanks to deterministic gene-gene interactions, which could have significant implications for medicine and environmental science. These findings not only shed light on the unexpected effects of climate change but also open doors to scientific progress beyond traditional boundaries and enhance our understanding of evolutionary processes.