#460 HFpEF: Heart Failure with Preserved Ejection Fraction

In this episode of The Curbsiders, Dr. Michelle Kittleson returns to discuss heart failure with preserved ejection fraction (HFpEF). The hosts and Dr. Kittleson discuss the challenges in diagnosing HFpEF, emphasizing the importance of ruling out other potential causes of dyspnea and edema, such as liver or kidney problems, and cardiac amyloidosis. Dr. Kittleson shares advice on the utility of the H2FpEF score and the importance of considering comorbidities. The discussion covers management strategies, including lifestyle interventions like weight loss and exercise, as well as guideline-directed medical therapy (GDMT) with SGLT2 inhibitors, MRAs, ARNIs, and ARBs. The episode also touches on the potential role of GLP-1 receptor agonists in HFpEF management and the importance of referral to a specialist when the diagnosis is unclear or treatment is ineffective.