In this podcast episode, the hosts delve into the fascinating history and future possibilities of bacteriophage therapy, highlighting the groundbreaking work of Felix d'Hérelle and the advancements in microbiology. They discuss key topics, including the differences between lytic and lysogenic phages, the complex interactions between bacteria and phages influenced by CRISPR defenses, and the exciting yet challenging realm of personalized phage therapies. Throughout the conversation, the hosts stress the importance of regulatory changes, public awareness, and innovative approaches to tackle antibiotic resistance, ultimately fostering a sense of hope for the role of phage therapy in modern medicine.