Alzheimer Disease as a Clinical-Biological Construct

The podcast explores the evolving definition and diagnostic criteria for Alzheimer's disease, highlighting the shift from a diagnosis of exclusion to a clinical-biological construct. Dr. Giovanni Frisoni discusses his work, emphasizing the importance of considering both clinical symptoms and pathological biomarkers for accurate diagnosis and treatment. He argues against diagnosing Alzheimer's solely based on biomarkers in cognitively normal individuals, citing data that many biomarker-positive individuals may never develop cognitive impairment. The discussion also covers the role of tau PET scans in identifying high-risk individuals and the need for tailored risk reduction interventions based on individual risk profiles, including lifestyle, vascular factors, and genetics.