AOSD - Adult-onset Still’s disease

Adult-onset Still's disease diagnosis and treatment are explored, emphasizing the importance of recognizing the classic triad of quotidian fever, evanescent rash, and polyarthritis for accurate diagnosis. A key point is the unreliability of ferritin levels as a sole diagnostic marker, as hyperferritinemia can result from various conditions. The lecture stresses that TNF inhibitors should be avoided for systemic disease. Instead, high-dose steroids combined with IL-1 or IL-6 inhibitors are recommended. The discussion also covers macrophage activation syndrome (MAS) as a severe complication, detailing its presentation and aggressive treatment approach using high-dose steroids and IL-1 or IL-6 inhibitors.