55. Macrophage Activation Syndrome

Macrophage Activation Syndrome (MAS), a hyperinflammatory response damaging multiple organs, is explored with Dr. Lauren Henderson, a pediatric rheumatologist. The discussion clarifies the confusing nomenclature surrounding MAS, HLH, and cytokine storms, attributing it to different medical specialties using distinct terms for similar conditions. It's highlighted that various insults, such as genetic conditions, infections, malignancies, or rheumatic diseases, can trigger this final common pathway of excessive inflammation. Dr. Henderson recounts her experience in resolving disagreements between rheumatologists and hematologists/oncologists regarding treatment approaches, eventually leading to a consensus-based guideline. The podcast further examines risk factors, diagnostic approaches, treatment strategies, and the impact of COVID-19 on hyperinflammatory syndromes, emphasizing the need for multidisciplinary teams and early intervention.