#150 HFpEF with Dr Clyde Yancy MD

This podcast addresses the complexities surrounding heart failure with preserved ejection fraction (HFpEF), challenging outdated notions and emphasizing the importance of accurate diagnosis through ejection fraction measurement. It features Dr. Clyde Yancy, who clarifies the distinction between diastolic dysfunction and HFpEF, advocating for a focus on the clinical syndrome of heart failure. The discussion explores various HFpEF phenotypes, including cardiometabolic, pulmonary hypertension-related, and cardiorenal, highlighting the role of inflammation and nitric oxide deficiency. Dr. Yancy shares insights on tailored treatment approaches, including SGLT2 inhibitors, mineralocorticoid antagonists, and potential future therapies like interatrial shunts, while stressing the need to address underlying comorbidities and lifestyle factors. He also underscores the importance of ischemic workup and advocates for aggressive diuresis in acute decompensation.