Here's a new paper on cancer developing in patients after receiving gene therapy with eli-cel, brand name Skysona.

What is eli-cel?

Stem cells are isolated and modified by using a lentiviral vector to add the ABCD1 gene. The stem cells in bone marrow are killed with chemotherapy, and replaced with the modified stem cells.

How often did cancer develop?

Hematologic cancer developed in 7 of 67 patients after the receipt of eli-cel

Yep, that's about what I expected. How long did it take?

myelodysplastic syndrome (MDS) with unilineage dysplasia in 2 patients at 14 and 26 months; MDS with excess blasts in 3 patients at 28, 42, and 92 months; MDS in 1 patient at 36 months; and acute myeloid leukemia (AML) in 1 patient at 57 months.

Makes sense. What does genetic analysis of the cancer cells indicate?

In the [...]

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First published:
October 16th, 2024

Source:
https://www.lesswrong.com/posts/gXmFCfh4SBz2oFuhv/cancer-rates-after-gene-therapy

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Narrated by TYPE III AUDIO.

“cancer rates after gene therapy” by bhauth

LessWrong (30+ Karma)