In this podcast episode, we explore the exciting field of cellular rejuvenation led by Juan Carlos Belmonte. He examines how we can potentially reverse aging and combat age-related diseases through innovative methods like partial reprogramming with Yamanaka factors. By moving away from a narrow focus on genetic mutations, Belmonte emphasizes the importance of cellular resilience and the epigenome's role in overall health. His insights offer a promising vision of rejuvenating not just individual cells but entire organs, opening up new therapeutic possibilities that combine lifestyle changes with cutting-edge scientific techniques.