In this podcast episode, the discussion centers on the dynamic field of phenomics and its vital role in advancing precision medicine. Unlike traditional methods that focus solely on genomic data, Dr. Nicholson and Dr. Hyman explore how the intricate interactions among individual biology, the microbiome, and environmental influences are crucial. They critique conventional healthcare models and urge a shift toward a phenome-driven approach, particularly in the early detection of biochemical signals in patients, such as those suffering from Long COVID. By harnessing artificial intelligence and machine learning to analyze health data, they envision a future where personalized medicine not only targets diseases but also promotes overall well-being, leading to more effective prevention and treatment strategies.