In this podcast episode, the hosts challenge conventional views of life, moving beyond the traditional focus on DNA and RNA to explore the possibility of alternative microbial forms on Earth. They delve into innovative theories like the shadow biosphere and introduce a new concept called "LYFE," which expands the definition of life to include diverse systems and processes. Through captivating examples and listener stories, the discussion invites audiences to rethink the diversity of life and the potential for discoveries in extreme environments, hinting that life may be a more universal phenomenon than we have ever imagined.