This podcast episode investigates the intricate role of Pharmacy Benefit Managers (PBMs) as intermediaries in the pharmaceutical industry, weighing their potential benefits against the conflicts of interest they may create. Through a hypothetical case study of a fictional drug called "Lifelixir," the episode highlights the opaque nature of PBM negotiations and how this opacity can drive up drug costs for consumers. It navigates through arguments from both supporters and detractors of PBMs, underscoring the necessity for transparency and informed competition in order to ensure fair drug pricing.